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    • Research & Paper

      연구성과 & 논문

    • 13

      [SFC바이오-근기능 개선 프로젝트] 논문 08. Fermented Whey Protein...

      1) 저널명 : Food Science of Animal Resources (2023) 2) 논문명 : Fermented Whey Protein Supplementation Improves Muscular Strength, Muscle Parameters, and Physical Performance in Middle-Aged Korean Adults: An 8-Week Double Blind Randomized Controlled Trial 3) 요약 The present study evaluated the effects of fermented whey protein using kimchi lactic acid bacteria Lactobacillus casei DK211 on skeletal muscle mass, muscle strength, and physical performance in healthy middle-aged males performing regu..

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    • 12

      [SFC바이오-관절 프로젝트] 논문 07. Efficacy of Perilla frutes...

      1) 저널명 : Frontier in Pharmacology (2023) 2) 논문명 : Efficacy of Perilla frutescens (L.) Britton var. frutescens extract on mild knee joint pain: A randomized controlled trial 3) 요약 Objectives: This study aimed to evaluate the clinical efficacy and safety of PE extracts developed for the purpose of relieving pain and improving knee joint function on semi-healthy people with mild knee joint pain. Methods: A randomized, double-blind, two-arm, single-center, placebocontrolled clinical trial was ..

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    • 11

      [SFC바이오-관절 프로젝트] 논문 06. The Efficacy and Safety of...

      1) 저널명 : J Food Science and Nutrition. 2005 2) 논문명 : The Efficacy and Safety of Beef Tallow Extract Including Cis - 9 - cetylmyristoleate in Patients with Osteoarthritis - As an Adjuvant Pharmacological Treatment - 3) 요약 In this double-blind, placebo-controlled trial, we assessed the efficacy and safety of beef tallow extract(BTE) including Cis-9-cetylmyristoleate in patients with arthritis. Between May and December 2003, we selected 80 patients (n=80) who sh..

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    • 10

      [SFC바이오-관절 프로젝트] 논문 05. Anti-Arthritic Effect of R...

      1) 저널명 : Journal of the Korean Applied Science and Technology 2) 논문명 : Anti-Arthritic Effect of Radiation Mutant Perilla frutescens var. crispa and Atractylodes macrophala koidz. 3) 요약 본 연구는 감마선을 이용한 육종 차조기 추출물을 통해 항염증 효능을 평가하고자 하였다. RAW 264.7 세포에서 MTT를 통해 세포 생존율을 평가하였으며, LPS로 유도한 RAW 264.7 세포에서 ROS, NO, 염증성 사이토카인, NF-κB, COX-2 등을 ELISA, Luminex 및 PCR로 측정하였다. 그 결과, 육종 차조기 추출물은 25 ㎍/㎖ 이하에서 세포독성이 없었으며, LPS로 유도된 RAW 264.7 세포에서 ROS, NO, 사이토카인(IL-1β, IL-6, TNF-α)의 생성을 억제하였다. ..

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    • 9

      [SFC바이오-관절 프로젝트] 논문 04. Effects of anti-inflammato...

      1) 저널명 : Journal of the Korean Applied Science and Technology 2) 논문명 : Effects of anti-inflammatory on Perilla frutescens var. crispa Induced by mutants with γ-Ray 3) 요약 본 연구에서는 방사선 육종 차조기와 백출의 복합추출물의 항관절염 효능을 평가하였다. 방사선 육종 차조기와 백출 복합추출물이 세포에 미치는 독성을 확인하기 위해 RAW 264.7 세포에서 MTT 기법으로 세포 생존율을 평가하였다. 방사선 육종 차조기와 백출 복합추출물의 항염증 효능을 확인하기 위해 LPS로 염증을 유도한 RAW 264.7 세포에 방사선 육종 차조기와 백출 복합추출물을 5, 10,25 ㎍/㎖ 농도로 처리한 후 ROS와 NO level, 염증성 사이토카인의 분비, 염증성 인자인 NF-κB, COX-2, iNOS 등의 발현을 측정하였다. 또한 ..

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    • 8

      [SFC바이오-관절 프로젝트] 논문 03. Isoegomaketone Alleviates ...

      1) 저널명 : Molecules, 2017 2) 논문명 : Isoegomaketone Alleviates the Development of Collagen Antibody-Induced Arthritis in Male Balb/c Mice 3) 요약 In this study, we attempted to identify and assess effects of isoegomaketone (IK) isolated from Perilla frutescens var. crispa on the development of rheumatoid arthritis (RA). RA was induced in male Balb/c mice by collagen antibody injection. Experimental animals were randomly divided into five groups: normal, collagen antibody-induced arthr..

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    • 7

      [SFC바이오-관절 프로젝트] 논문 02. A New Monoterpene from the...

      1) 저널명 : Molecules, 2017 2) 논문명 : A New Monoterpene from the Leaves of a Radiation Mutant Cultivar of Perilla frutescens var. crispa with Inhibitory Activity on LPS-Induced NO Production 3) 요약 The leaves of Perilla frutescens var. crispa (Lamiaceae)—known as ‘Jureum-soyeop’ or ‘Cha-jo-ki’ in Korean, ‘ZI SU YE’ in Chinese, and ‘Shiso’ in Japan—has been used as a medicinal herb. Recent gamma irradiated mutation breeding on P. frutescens var. crispa in our research group resulted in..

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    • 6

      [SFC바이오-관절 프로젝트] 논문 01. Anti-Arthritic Activities ...

      1) 저널명 : Nutrients. 2019 2) 논문명 : Anti-Arthritic Activities of Supercritical Carbon Dioxide Extract Derived from Radiation Mutant Perilla Frutescens Var. Crispa in Collagen Antibody-Induced Arthritis 3) 요약 We investigated the anti-arthritic e ects of the radiation mutant Perilla frutescens var. crispa leaf extract (SFE-M) and wild type leaf extract (SFE-W), both prepared by supercritical carbon dioxide (SC-CO2) extraction, on collagen antibody-induced arthritis (CAIA) in Balb/c mic..

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    • 5

      [SFC바이오-알츠하이머 프로젝트] 논문 02. Effect of natural antio...

      1) 저널명 : Tropical Journal of Pharmaceutical Research 2) 논문명 : Effect of natural antioxidants on the aggregation and disaggregation of beta-amyloid 3) 요약 (1) 목적 : To examine the relationship between higher antioxidant activity and aggregation or disaggregation of beta-amyloid (Aβ) for 21 plants. (2) 대상 및 방법 : Twenty-nine natural plant extracts and their antioxidant activities were analyzed using DPPH assay. The aggregation and disaggregation of Aβ were analyzed using Thioflavin-T assay..

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    • 4

      [SFC바이오-알츠하이머 프로젝트] 논문 01. Anti-amyloidogenic effe...

      1) 저널명 : Journal of Food Biochemistry 2) 논문명 : Anti-amyloidogenic effects of Perilla frutescens var. acuta on beta-amyloid aggregation and disaggregation 3) 요약 Beta-amyloid (Ab) aggregates are a major cause of Alzheimer’s disease (AD), and the inhibition of Ab aggregation is a good therapeutic target against AD. Thus, the effects of Perilla extract (4–100mg/mL) on the aggregation of Ab (20 mM) monomers and disaggregation of pre-aggregated Ab aggregates were determined. The P..

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    • 3

      [SFC바이오-헬리코박터 프로젝트] 논문 03. Inhibitory Effects of β...

      1) 저널명 : The Korean Journal of Gastroenterology 2) 논문명 : Inhibitory Effects of β-caryophyllene on Helicobacter pylori Infection: A Randomized Double-blind, Placebo-controlled Study 3) 요약 (1) 목적 : H. pylori infection은 한국에서 흔한 병으로 여러 위장관 증상을 일으키며, 최근 제균 성공률이 낮아지고 있다. 베타카리오필렌은 천연 화합물로 항염증 효과와 항균 효과가 있다고 최근에 보고되고 있다. 우리는 베타카리오필렌의 H. pylori감염 억제 효능을 평가하고, 위장관 질환의 치료제로서의 가능성을 알아보고자 하였다. (2) 대상 및 방법 : 2018년 3월부터 2019년 6월까지 H. pylori 양성을 진단받은 총 66명의 환자를 대상으로 무작위 배정, 양측 눈가림, 위약..

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    • 2

      [SFC바이오-헬리코박터 프로젝트] 논문 02. Inhibitory Effects of ...

      1) 저널명 : International Journal of Molecular Science (IF 4.18) 2) 논문명 : Inhibitory Effects of b -Caryophyllene on Helicobacter pylori Infection In Vitro and In Vivo 3) 요약 The human specific bacterial pathogen Helicobacter pylori (H. pylori) is associated with severe gastric diseases, including gastric cancer. Recently, the increasing resistance makes the usage of antibiotics less e ectively. Therefore, development of a new antimicrobial agent is required to control H. pylori ..

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    • 1

      [SFC바이오-헬리코박터 프로젝트] 논문 01. Effect of b-caryophylle...

      1) 저널명 : Nutrients ( IF 4.17) 2) 논문명 : Effect of b-caryophyllene from cloves extract on Helicobacter pylori eradication in mouse model 3) 요약 New antibacterial treatments against Helicobacter pylori are needed as H. pylori is acquiring antibiotic resistance. b-caryophyllene is a natural bicyclic sesquiterpene, with anti-inflammatory and antimicrobial effects. This study investigates the e ects of H-002119-00-001 from -caryophyllene on the eradication of H. pylori in a mo..

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